4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine

Base Information

• Chemical Name: 4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine
• CAS No.: 480453-85-8
• Molecular Formula: C₂₀H₁₉FN₆
• Molecular Weight: 362.409
• Mol file: 480453-85-8.mol

Synonyms:4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine

Chemical Property of 4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine

There total 16 articles about 4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

[2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine (480458-37-5) → 4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine (480453-85-8)

Guidance literature:

With ammonia; In tetrahydrofuran; at 20 ℃; for 12h; under 2844.39 Torr;

DOI:10.1016/j.ejmech.2007.02.006

Reference yield:

2-methylthio-4-methylpyrimidine (14001-63-9) → 4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine (480453-85-8)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium diisopropylamide / tetrahydrofuran

2: tetra-n-butylammonium tribromide / CH₂Cl₂

3: ethanol / 60 °C

4: oxone

5: NH₃

6: Et₃N

7: i-Pr₂NEt

With Oxone; ammonia; tetra-N-butylammonium tribromide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.08.127

Reference yield:

methyl 4-flurobenzoate (403-33-8) → 4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine (480453-85-8)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium diisopropylamide / tetrahydrofuran

2: tetra-n-butylammonium tribromide / CH₂Cl₂

3: ethanol / 60 °C

4: oxone

5: NH₃

6: Et₃N

7: i-Pr₂NEt

With Oxone; ammonia; tetra-N-butylammonium tribromide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.08.127

upstream raw materials:

[2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine

methanesulfonic acid 3-(2-amino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridin-7-ylmethyl ester

dimethyl amine

[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol

Downstream raw materials:

C₂₀H₁₈BrFN₆

C₂₁H₁₉FN₆O

C₂₆H₂₇FN₆O

C₂₃H₂₃FN₆O