4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime

Base Information

Chemical Name:4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime
CAS No.:1407965-47-2
Molecular Formula:C₂₂H₂₄F₅N₅O
Molecular Weight:469.457
Hs Code.:

Synonyms:4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime

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Chemical Property of 4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime

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Technology Process of 4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime

There total 9 articles about 4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1393685-68-1
4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid tert-butyl ester

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1407965-47-2
4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime

Guidance literature:: 4-[4-(4-amino-2,5-difluorophenyl)cyclohexylideneaminooxy]piperidin-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;

2-chloro-4-trifluoromethylpyrimidine; With triethylamine; In dichloromethane;

Reference yield:

: 167415-27-2
1-bromo-2,5-difluoro-4-nitrobenzene

: 1407965-47-2
4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 12 h

3: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

4: water; tetrahydrofuran; methanol / 2 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; water / 2 h / 0 - 20 °C

With hydrogenchloride; hydrogen; sodium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 1393685-65-8
8-(2,5-difluoro-4-nitrophenyl)-1,4-dioxa-spiro[4.5]dec-7-ene

: 1407965-47-2
4-(4-amino-2,5-difluoro-phenyl)cyclohexanone O-[1-(4-trifluoromethyl-pyrimidin-2-yl)piperidin-4-yl]oxime

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 12 h

2: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

3: water; tetrahydrofuran; methanol / 2 h / 20 °C

4: hydrogenchloride / 1,4-dioxane; water / 2 h / 0 - 20 °C

With hydrogenchloride; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;