N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

Base Information

Chemical Name:N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine
CAS No.:1400691-92-0
Molecular Formula:C₂₁H₂₂F₄N₆O
Molecular Weight:450.439
Hs Code.:

Synonyms:N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

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Chemical Property of N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

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Technology Process of N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

There total 6 articles about N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 68322-84-9
2-bromo-1-fluoro-4-(trifluoromethyl)benzene

: 1400692-22-9
C₁₄H₂₀N₆O

: 1400691-92-0
N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; at 170 ℃; for 1.5h;

Reference yield:

: 1400692-05-8
C₁₁H₁₆N₂O

: 1400691-92-0
N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1 h / 20 °C

2: isopropyl alcohol / 16 h / Reflux

3: caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 1.5 h / 170 °C

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1400691-92-0
N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-3-{4-[(2-methyl-4-pyridinyl)oxy]-1-piperidinyl}-1H-1,2,4-triazol-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / dimethyl sulfoxide / 1 h / 20 °C

1.2: 48 h / 50 °C

2.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 20 °C

3.1: dichloromethane / 1 h / 20 °C

4.1: isopropyl alcohol / 16 h / Reflux

5.1: caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 1.5 h / 170 °C

With hydrogenchloride; copper(l) iodide; caesium carbonate; sodium t-butanolate; N,N`-dimethylethylenediamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;