4-BENZYLOXY-2-FLUORO-1-NITROBENZENE

Base Information

• Chemical Name: 4-BENZYLOXY-2-FLUORO-1-NITROBENZENE
• CAS No.: 221040-07-9
• Molecular Formula: C13H10 F N O3
• Molecular Weight: 247.226
• Hs Code.: 2909309090
• Mol file: 221040-07-9.mol

Synonyms:2-Fluoro-4-(benzyloxy)nitrobenzene;4-Benzyloxy-2-fluoro-1-nitrobenzene

Chemical Property of 4-BENZYLOXY-2-FLUORO-1-NITROBENZENE

Chemical Property:

• Boiling Point: 385.3°Cat760mmHg
• Flash Point: 186.8°C
• PSA: 55.05000
• Density: 1.299g/cm³
• LogP: 3.83610

Purity/Quality:

97% ^*data from raw suppliers

4-Benzyloxy-2-fluoro-1-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 36/37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BENZYLOXY-2-FLUORO-1-NITROBENZENE

There total 6 articles about 4-BENZYLOXY-2-FLUORO-1-NITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-4-nitrophenol (394-41-2) + benzyl bromide (100-39-0) → 4-benzyloxy-2-fluoro-1-nitrobenzene (221040-07-9)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2008.06.043

Reference yield: 91.0%

2,4-Difluoronitrobenzene (446-35-5) + benzyl bromide (100-39-0) → 4-benzyloxy-2-fluoro-1-nitrobenzene (221040-07-9)

Guidance literature:

2,4-Difluoronitrobenzene; benzyl bromide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

Reference yield:

3-fluoro-4-nitrophenol (394-41-2) + benzyl bromide (100-39-0) + tetra-(n-butyl)ammonium iodide (311-28-4) → 4-benzyloxy-2-fluoro-1-nitrobenzene (221040-07-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

3-fluoro-4-nitrophenol

benzyl bromide

tetra-(n-butyl)ammonium iodide

2,4-Difluoronitrobenzene

Downstream raw materials:

N-(5-benzyloxy-2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

N-(5-benzyloxy-2-nitrophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

5-(benzyloxy)-N-methyl-2-nitroaniline

5-(benzyloxy)-N₁-methylbenzene-1,2-diamine

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