4-(4-Hydroxyphenyl)quinoline

Base Information

• Chemical Name: 4-(4-Hydroxyphenyl)quinoline
• CAS No.: 156970-36-4
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.258
• Mol file: 156970-36-4.mol

Synonyms:4-(4-Hydroxyphenyl)quinoline

Chemical Property of 4-(4-Hydroxyphenyl)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Hydroxyphenyl)quinoline

There total 6 articles about 4-(4-Hydroxyphenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(3,5-Di-tert-butyl-4-hydroxyphenyl)quinoline → 4-(4-Hydroxyphenyl)quinoline (156970-36-4)

Guidance literature:

With trifluorormethanesulfonic acid; toluene; at 100 ℃; for 3h;

DOI:10.1021/jo00095a024

Reference yield:

4-chloroquinoline (611-35-8) → 4-(4-Hydroxyphenyl)quinoline (156970-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / potassium tert-butoxide, quinoxaline / liquid ammonia / -38 °C / electrosynthesis: cathode - platinum grid, 10 cm², 1024 mesh/cm²; anode - magnesium rod, h = 8 cm, Φ = 1 cm; constant current density 0,5 A dm^-2, KBr as supporting electrolyte

2: 87 percent / toluene, CF₃SO₃H / 3 h / 100 °C

With 2,3-diethynylquinoxaline; trifluorormethanesulfonic acid; potassium tert-butylate; toluene; In ammonia;

DOI:10.1021/jo00095a024

Reference yield:

→ 4-(4-Hydroxyphenyl)quinoline (156970-36-4)

Guidance literature:

at 250 ℃;

upstream raw materials:

4-(p-aminophenyl)-quinoline

4-chloroquinoline

4-phenylquinoline

Downstream raw materials:

4-quinolinic acid