(5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate

Base Information

Chemical Name:(5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate
CAS No.:1424403-24-6
Molecular Formula:C₂₇H₄₄O₅
Molecular Weight:448.643
Hs Code.:

Synonyms:(5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate

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Chemical Property of (5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate

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Technology Process of (5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate

There total 14 articles about (5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1403236-07-6
(5R,7R)-methyl 7-hydroxy-5,8,8-trimethylnonanoate

: 1424403-05-3
(R)-6-(benzyloxy)-2-methylhexanoic acid

: 1424403-24-6
(5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate

Guidance literature:: (R)-6-(benzyloxy)-2-methylhexanoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

(5R,7R)-methyl 7-hydroxy-5,8,8-trimethylnonanoate; With dmap; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2013.01.048

Reference yield:

: 4(R)-benzyl-3-<6-(benzyloxy)hexanoyl>oxazolidin-2-one

: 1424403-24-6
(5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C / Cooling with ice

3.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 12 h / 0 - 20 °C / Inert atmosphere

With 2,4,6-trichlorobenzoyl chloride; dihydrogen peroxide; sodium hexamethyldisilazane; triethylamine; lithium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2013.01.048

Reference yield:

: 1424403-04-2
(R)-4-benzyl-3-((R)-6-(benzyloxy)-2-methylhexanoyl)oxazolidin-2-one

: 1424403-24-6
(5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C / Cooling with ice

2.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 0 - 20 °C / Inert atmosphere

With 2,4,6-trichlorobenzoyl chloride; dihydrogen peroxide; triethylamine; lithium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2013.01.048