Technology Process of (R)-6-(benzyloxy)-2-methylhexanoic acid
There total 7 articles about (R)-6-(benzyloxy)-2-methylhexanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; lithium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 3h;
Cooling with ice;
DOI:10.1016/j.tet.2013.01.048
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 - 0 °C / Inert atmosphere
2.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 1 h / 20 °C
3.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / -20 °C
3.2: 2 h / -20 - 0 °C
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: 3 h / -78 °C / Inert atmosphere
5.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C / Cooling with ice
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dihydrogen peroxide; sodium hexamethyldisilazane; pivaloyl chloride; dimethyl sulfoxide; triethylamine; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tet.2013.01.048
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 1 h / -20 °C
1.2: 2 h / -20 - 0 °C
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 °C / Inert atmosphere
3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C / Cooling with ice
With
dihydrogen peroxide; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; water;
DOI:10.1016/j.tet.2013.01.048
