2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester
• CAS No.: 172919-07-2
• Molecular Formula: C₁₄H₁₇BrO₂
• Molecular Weight: 297.192
• Mol file: 172919-07-2.mol

Synonyms:2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester

Chemical Property of 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester

There total 4 articles about 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2E)-3-(4-bromophenyl)prop-2-en-1-ol (105515-33-1) + pivaloyl chloride (3282-30-2) → 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester (172919-07-2)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; for 6h; 0 deg C -> RT;

DOI:10.1016/0040-4039(95)01987-S

Reference yield:

ethyl (E)-3-(4-bromophenyl)-2-propenoate (24393-53-1,136265-11-7,15795-20-7) → 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester (172919-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / DIBAL-H / CH₂Cl₂; hexane / 0.17 h / -78 °C

2: 87 percent / pyridine / dimethylformamide / 6 h / 0 - 25 °C

With pyridine; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester (172919-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / benzene / 0.5 h / 25 °C

2: 97 percent / DIBAL-H / CH₂Cl₂; hexane / 0.17 h / -78 °C

3: 87 percent / pyridine / dimethylformamide / 6 h / 0 - 25 °C

With pyridine; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1002/(SICI)1521-3765(199801)4:1<33::AID-CHEM33>3.0.CO;2-8

upstream raw materials:

(2E)-3-(4-bromophenyl)prop-2-en-1-ol

pivaloyl chloride

ethyl (E)-3-(4-bromophenyl)-2-propenoate

4-bromo-benzaldehyde

Downstream raw materials:

2,2-Dimethyl-propionic acid (E)-3-{4-[2-benzyloxy-5-(2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-allyl ester

combretastatin D-2

(13R,14R)-4-benzyloxy-13,14-dihydroxy-2,11-dioxatricyclo[13.2.2.1^3,7]eicosa-1⁽¹⁸⁾,3,5,7⁽²⁰⁾,1⁽¹⁹⁾,16-hexaen-10-one

2,2-Dimethyl-propionic acid (2R,3R)-3-{4-[2-benzyloxy-5-(2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-2,3-dihydroxy-propyl ester