Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester
CAS No.:326853-58-1
Molecular Formula:C₃₃H₆₀O₈SSi₂
Molecular Weight:673.072
Hs Code.:

Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Synonyms:Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Suppliers and Price of Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

There total 15 articles about Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: (2R,3R,8S,9S)-1-Benzyloxy-2,8-bis-(tert-butyl-dimethyl-silanyloxy)-9-(2-methoxy-ethoxymethoxy)-undec-5-yn-3-ol

: 326853-58-1
Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane;
DOI:10.1016/S0040-4039(00)01880-3

Reference yield:

: 326853-65-0
(4S,5S)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane

: 326853-58-1
Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / H₂ / Pd(OH)2 / ethyl acetate

2: DMAP; TEA / CH₂Cl₂

3: Amberlyst 15 / methanol

4: 94 percent / K₂CO₃ / methanol; CH₂Cl₂

5: 89 percent / i-Pr₂NEt; DMAP / 1,2-dichloro-ethane / 50 °C

6: 91 percent / dimethylsulfoxide / 0 °C

7: 79 percent / NaH / tetrahydrofuran

8: 76 percent / n-BuLi; BF₃*OEt₂ / tetrahydrofuran / -78 °C

9: 99 percent / DMAP; Pyridine / CH₂Cl₂

With pyridine; dmap; n-butyllithium; Amberlyst 15; TEA; boron trifluoride diethyl etherate; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane; 8: Yamaguchi reaction;
DOI:10.1016/S0040-4039(00)01880-3

Reference yield:

: 78469-78-0
(4R,5R)-p-toluolsulfonsaeure<(5-benzyloxymethyl-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl>ester

: 326853-58-1
Methanesulfonic acid (1R,6S,7S)-1-[(R)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(tert-butyl-dimethyl-silanyloxy)-7-methoxymethoxy-non-3-ynyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / Amberlyst 15 / methanol

2: 87 percent / K₂CO₃ / methanol; CH₂Cl₂

3: 96 percent / AgNO₃; pyridine / acetonitrile

4: 76 percent / n-BuLi; BF₃*OEt₂ / tetrahydrofuran / -78 °C

5: 99 percent / DMAP; Pyridine / CH₂Cl₂

With pyridine; dmap; n-butyllithium; Amberlyst 15; boron trifluoride diethyl etherate; potassium carbonate; silver nitrate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 4: Yamaguchi reaction;
DOI:10.1016/S0040-4039(00)01880-3