5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid

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Chemical Name:5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid
CAS No.:1073186-74-9
Molecular Formula:C₂₈H₄₂N₂O₆S₂
Molecular Weight:566.783
Hs Code.:

Synonyms:5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid

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Chemical Property of 5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid

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Technology Process of 5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid

There total 8 articles about 5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1073187-00-4
5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester

: 1073186-74-9
5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: 5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; water; In tetrahydrofuran; pH=~ 4;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1073186-74-9
5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 16.75 h / 0 - 20 °C

2.1: caesium carbonate / butanone / 8 h / 60 °C

2.2: 16.5 h / 20 °C

2.3: 0.5 h

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

5.1: methanol; sodium hydroxide; water / tetrahydrofuran / 15 h / 20 °C

5.2: pH ~ 4

With methanol; sodium hydroxide; water; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; butanone;

Reference yield:

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1073186-74-9
5-{4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)-phenylsulfanyl]-piperidine-1-sulfonyl}-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / butanone / 8 h / 60 °C

1.2: 16.5 h / 20 °C

1.3: 0.5 h

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

4.1: methanol; sodium hydroxide; water / tetrahydrofuran / 15 h / 20 °C

4.2: pH ~ 4

With methanol; sodium hydroxide; water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; butanone;