3-fluoro-N-methylpyridin-2-amine

Base Information

Chemical Name:3-fluoro-N-methylpyridin-2-amine
CAS No.:220714-69-2
Molecular Formula:C₆H₇FN₂
Molecular Weight:126.133
Hs Code.:
European Community (EC) Number:852-707-6
Nikkaji Number:J1.098.287A
ChEMBL ID:CHEMBL4552031
Mol file:220714-69-2.mol

Synonyms:3-fluoro-N-methylpyridin-2-amine;220714-69-2;SCHEMBL361055;CHEMBL4552031;AMVFJTOQPSFLIL-UHFFFAOYSA-N;3-Fluoro-N-methylpyridine-2-amine;(3-Fluoro-pyridin-2-yl)-methylamine;AKOS012027014;AM86765;CS-0222938;EN300-113298;A903747;Z997723632

Suppliers and Price of 3-fluoro-N-methylpyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-fluoro-N-methylpyridin-2-amine
250mg
$ 350.00

TRC
3-fluoro-N-methylpyridin-2-amine
50mg
$ 90.00

Matrix Scientific
3-Fluoro-N-methylpyridin-2-amine 95%
1g
$ 445.00

Total 4 raw suppliers

Chemical Property of 3-fluoro-N-methylpyridin-2-amine

Chemical Property:

Boiling Point:186.4±25.0 °C(Predicted)
PKA:4.49±0.10(Predicted)
PSA：0.00000
Density:1.186±0.06 g/cm3(Predicted)
LogP:0.00000
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:126.05932639
Heavy Atom Count:9
Complexity:87.1

Purity/Quality:

97% ^*data from raw suppliers

3-fluoro-N-methylpyridin-2-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CNC1=C(C=CC=N1)F

Technology Process of 3-fluoro-N-methylpyridin-2-amine

There total 4 articles about 3-fluoro-N-methylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: N-[(3'-fluoropyridin-2'-yl)methylamino]pyridinium iodide

: 220714-69-2
(3-fluoropyridin-2-yl)methylamine

Guidance literature:: With ammonium formate; platinum on activated charcoal; In methanol; for 168h; Heating;
DOI:10.1021/jo9813540

Reference yield: 50.0%

: 17282-04-1
2-chloro-3-fluoropyridine

: 74-89-5
methylamine

: 220714-69-2
(3-fluoropyridin-2-yl)methylamine

Guidance literature:: In methanol; at 80 ℃; for 72h;
DOI:10.1039/d1cc05076a

Reference yield:

: 46224-49-1
(pyridin-1-iumyl)[(pyridin-2-yl)aminide]

: 220714-69-2
(3-fluoropyridin-2-yl)methylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / XeF₂; K₂CO₃ / CH₂Cl₂ / 0.5 h / -40 °C

2: 83 percent / acetone / 24 h / 20 °C

3: 84 percent / ammonium formate / Pt/C / methanol / 168 h / Heating

With xenon difluoride; ammonium formate; potassium carbonate; platinum on activated charcoal; In methanol; dichloromethane; acetone; 1: Fluorination / 2: Methylation / 3: Hydrogenolysis;
DOI:10.1021/jo9813540