2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone

Base Information

• Chemical Name: 2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone
• CAS No.: 943827-53-0
• Molecular Formula: C₂₇H₂₈O₉
• Molecular Weight: 496.514
• Mol file: 943827-53-0.mol

Synonyms:2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone

Chemical Property of 2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone

There total 3 articles about 2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-methoxy-1-[2-hydroxy-4,6-bis(methoxymethyloxy)phenyl]ethanone (943827-52-9) + p-(benzyloxy)benzoic acid (1486-51-7) → 2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone (943827-53-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/jo070502w

Reference yield:

3,5-dihydroxyphenol (108-73-6) → 2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone (943827-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / ZnCl₂; HCl / diethyl ether / 48 h

2: 68 percent / K₂CO₃ / acetone / 22 h / 20 °C

3: 82 percent / DMAP; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 15 h / 20 °C

With hydrogenchloride; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc(II) chloride; In diethyl ether; dichloromethane; acetone;

DOI:10.1021/jo070502w

Reference yield:

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone (55317-02-7) → 2-methoxy-1-[2-(p-benzyloxybenzoyloxy)-4,6-bis(methoxymethyloxy)phenyl]ethanone (943827-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / K₂CO₃ / acetone / 22 h / 20 °C

2: 82 percent / DMAP; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 15 h / 20 °C

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone;

DOI:10.1021/jo070502w

upstream raw materials:

2-methoxy-1-[2-hydroxy-4,6-bis(methoxymethyloxy)phenyl]ethanone

p-(benzyloxy)benzoic acid

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone

3,5-dihydroxyphenol

Downstream raw materials:

4'-benzyloxy-5-hydroxy-3-methoxy-7-(methoxymethyloxy)flavone

kaempferitrin

4'-benzyloxy-3,7-O-(2'',3'',4''-triacetyloxy-α-L-rhamnopyranosyl)-5-[((4-methylphenyl)sulfonyl)oxy]flavone

4'-benzyloxy-3,7-dihydroxy-5-[((4-methylphenyl)sulfonyl)oxy]flavone