N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

Base Information

Chemical Name:N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol
CAS No.:306740-58-9
Molecular Formula:C₆₃H₆₆FN₃O₂S₂
Molecular Weight:980.366
Hs Code.:

Synonyms:N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

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Chemical Property of N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

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Technology Process of N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

There total 9 articles about N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 189818-57-3
N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol

: 306740-56-7
2β-(1-propanoyl)-3β-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane

: 306740-58-9
N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 20h; Heating;
DOI:10.1021/jm0301484

Reference yield:

: 50370-59-7
2β-carbomethoxy-3β-(4-fluorophenyl)tropane

: 306740-58-9
N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / H₂O / dioxane / 24 h / Heating

2.1: (COCl)2; DMF / CH₂Cl₂ / 0.75 h / 22 °C

3.1: 960 mg / pyridine / CH₂Cl₂ / 1 h

4.1: 65 percent / tetrahydrofuran; diethyl ether / 4 h / 0 - 22 °C

5.1: 1-chloroethyl chloroformate / 2 h / 135 °C

5.2: 33 percent / MeOH / 1 h / Heating

6.1: 46 percent / KI; K₂CO₃ / acetonitrile / 20 h / Heating

With pyridine; oxalyl dichloride; carbonochloridic acid 1-chloro-ethyl ester; water; potassium carbonate; N,N-dimethyl-formamide; potassium iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm0301484

Reference yield:

: 85506-18-9
(1R)-(-)-2-carbomethoxy-3-tropinone

: 306740-58-9
N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium bistrimethylsilylamide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 97 percent / tetrahydrofuran / -78 - 22 °C

2.1: 89 percent / LiCl; aq. Na₂CO₃; Pd₂dba3 / various solvent(s) / 3 h / Heating

3.1: SmI₂ / tetrahydrofuran / 0.75 h / -78 °C

3.2: 34 percent / MeOH / tetrahydrofuran / 2 h

4.1: 95 percent / H₂O / dioxane / 24 h / Heating

5.1: (COCl)2; DMF / CH₂Cl₂ / 0.75 h / 22 °C

6.1: 960 mg / pyridine / CH₂Cl₂ / 1 h

7.1: 65 percent / tetrahydrofuran; diethyl ether / 4 h / 0 - 22 °C

8.1: 1-chloroethyl chloroformate / 2 h / 135 °C

8.2: 33 percent / MeOH / 1 h / Heating

9.1: 46 percent / KI; K₂CO₃ / acetonitrile / 20 h / Heating

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; samarium diiodide; oxalyl dichloride; carbonochloridic acid 1-chloro-ethyl ester; water; sodium hexamethyldisilazane; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; potassium iodide; lithium chloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; acetonitrile; 2.1: Suzuki coupling;
DOI:10.1021/jm0301484