189818-57-3

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 152863-83-7 N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide 
• 1095-85-8 2-amino tritylthio ethane 
• 122876-21-5 3-chloro-1-trifluoromethanesulfonyloxy-propane 

Downstream Products

• 306740-87-4 N-[2-(3'-N'-propyl-(1''R)-3''-(4-fluorophenyl)trop-2-ene-2''-(methoxycarbonyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 306740-88-5 N-[2-(3'-N'-propyl-(1''R)-3''-(3,4-dichlorophenyl)trop-2-ene-2''-(methoxycarbonyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 306740-58-9 N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 306740-69-2 N-[2-(3'-N'-propyl-(1''R)-3''α-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 306740-59-0 N-[2-(3'-N'-propyl-(1''R)-3''β-(3,4-dichlorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 306740-70-5 N-[2-(3'-N'-propyl-(1''R)-3''α-(3,4-dichlorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 919344-52-8 8-[3-((2-[4-(2-methoxyphenyl)piperazine-1-yl]-ethyl)pyridine-2-yl-amino)propyl]-[1,2,5,8]dithiadiazecan-6-one 
• 1378235-91-6 C₅₇H₇₂N₆OS₂ 
• 189818-58-4 N-[2-(3'-N'-propyl-(1R-3β-(4-fluorophenyl)-2β-methoxycarbonyltropane))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-2-aminoethanethiol 
• 306740-96-5 N-[2-((3'-N'-propyl-(1R)-3α-(4-fluorophenyl)-2β-methoxycarbonyl-tropane))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 190719-16-5 N-[2-((3'-N'-propyl-(1R-3β-(3,4-dichlorophenyl)-2β-methoxycarbonyltropane))(2-mercaptoethyl)amino)acetyl]-2-aminoethanethiol 
• 306740-73-8 N-[2-(3'-N'-propyl-(1R)-3α-(4-fluorophenyl)tropane-2β-(methoxymethylcarbamoyl))((2-((triphenylmethyl)thio)ethyl)-amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 

Relevant academic research and scientific papers

Highly efficient synthesis and imaging studies of an arylpiperazine derivative as a 5-HT1A receptor imaging agent

A novel and straightforward microwave synthesis of a new arylpiperazine derivative 3 which has an N2S2 moiety has been developed and radiolabeled with an optimum radionuclide of technetium in the presence of a borohydride exchange re

Tc-labeled arylpiperazine derivatives for imaging serotonin receptor

The present invention relates to Tc-labeled arylpiperazine derivatives for imaging serotonin receptor and, more particularly, to arylpiperazine derivatives coupled with MAMA-disulfide, N2S2 or dimethyl-N2S2 chel

Intermediates for the synthesis of radiolabelled tropanes

The compounds of the present invention comprise a tropane compound or ligand that selectively binds to tropane recognition sites, e.g., neuron transporters such as that DAT. The tropane ligand is radiolabeled with a radioactive technetium or rhenium by a chelating ligand which is attached to the tropane ligand by a linker. Tropane compounds or ligands useful in the pratice of the present invention can generally be represented by formula II where R1 and R2 are defined as above and where R1 can also be substituted at the C4 position of the tropane ring: Any tropane compound of the general formula II is useful in the present invention so long as it binds to DAT. Useful tropane analogs have a 3α-group,i.e., are of the boat configuration. Intermediates for the synthesis of the radiolabeled tropanes are claimed.

Technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain

The dopamine transporter (DAT), located presynaptically on dopamine neurons, provides a marker for certain neurological diseases. In particular, the DAT is depleted in Parkinson's disease, and the extent of depletion correlates with the loss of dopamine.