N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol

Base Information

• Chemical Name: N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol
• CAS No.: 189818-57-3
• Molecular Formula: C₄₇H₄₇ClN₂OS₂
• Molecular Weight: 755.488
• Mol file: 189818-57-3.mol

Synonyms:N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol

Chemical Property of N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol

There total 3 articles about N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-chloro-1-trifluoromethanesulfonyloxy-propane (122876-21-5) + N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide (152863-83-7) → N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol (189818-57-3)

Guidance literature:

In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm960868t

Reference yield: 61.0%

1.3-chlorobromopropane (109-70-6) + N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide (152863-83-7) → N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol (189818-57-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

2-amino tritylthio ethane (1095-85-8) → N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol (189818-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.25 h / -20 °C

2: Et₃N / CH₂Cl₂ / 24 h / 20 °C

3: K₂CO₃ / acetonitrile / 24 h / Heating

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1246/cl.2006.1304

upstream raw materials:

3-chloro-1-trifluoromethanesulfonyloxy-propane

N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide

1.3-chlorobromopropane

2-amino tritylthio ethane

Downstream raw materials:

N-[2-(3'-N'-propyl-(1''R)-3''-(4-fluorophenyl)trop-2-ene-2''-(methoxycarbonyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

N-[2-(3'-N'-propyl-(1''R)-3''-(3,4-dichlorophenyl)trop-2-ene-2''-(methoxycarbonyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol

N-[2-(3'-N'-propyl-(1''R)-3''α-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol