4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Base Information

• Chemical Name: 4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
• CAS No.: 791609-83-1
• Molecular Formula: C₂₄H₂₂N₆O
• Molecular Weight: 410.478
• Mol file: 791609-83-1.mol

Synonyms:4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Chemical Property of 4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

There total 7 articles about 4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-(azidomethyl)-N-((4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide → 4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (791609-83-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2018.03.003

Reference yield: 66.0%

4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide (404844-11-7) → 4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (791609-83-1)

Guidance literature:

4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide; With sodium azide; In N,N-dimethyl-formamide; at 20 ℃;

With 5%-palladium/activated carbon; hydrogen; In N,N-dimethyl-formamide; at 20 ℃; for 6h; under 760.051 Torr;

Reference yield:

C29H30N6O3 → 4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (791609-83-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.8b02007

upstream raw materials:

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

p-(chloromethyl)benzoyl chloride

4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide

4-(tert-Butoxycarbonylaminomethyl)benzoic acid

Downstream raw materials:

4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide