4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Base Information

• Chemical Name: 4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
• CAS No.: 1089724-90-2
• Molecular Formula: C₂₇H₂₄N₆O₂
• Molecular Weight: 464.527
• Mol file: 1089724-90-2.mol

Synonyms:4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Chemical Property of 4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

There total 5 articles about 4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (791609-83-1) + acryloyl chloride (814-68-6,25189-84-8) → 4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (1089724-90-2)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; Alkaline conditions;

DOI:10.1016/j.ejmech.2018.03.003

Reference yield:

4-(azidomethyl)-N-((4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide → 4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (1089724-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / 6 h / 20 °C

2: N,N-dimethyl-formamide / 0 °C / Alkaline conditions

With palladium on activated charcoal; hydrogen; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.03.003

Reference yield:

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine (152460-10-1) → 4-(acrylamidomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (1089724-90-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 0 °C / Alkaline conditions

2: sodium azide / N,N-dimethyl-formamide / 20 °C

3: palladium on activated charcoal; hydrogen / 6 h / 20 °C

4: N,N-dimethyl-formamide / 0 °C / Alkaline conditions

With sodium azide; palladium on activated charcoal; hydrogen; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.03.003

upstream raw materials:

4-(aminomethyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

acryloyl chloride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

p-(chloromethyl)benzoyl chloride