N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

Base Information

Chemical Name:N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide
CAS No.:1332498-30-2
Molecular Formula:C₁₄H₁₇N₃O₄S
Molecular Weight:323.373
Hs Code.:

Synonyms:N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

Suppliers and Price of N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

There total 10 articles about N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₆BBr₂N₃O₄S

: 1332498-30-2
N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

Guidance literature:: C₁₄H₁₆BBr₂N₃O₄S; With methanol; In dichloromethane; at 0 - 20 ℃;

With sodium carbonate; In methanol; chloroform; at 0 ℃; pH=8;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1332498-30-2
N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: ammonium nitrate; trifluoroacetic anhydride / 7.25 h / 0 - 20 °C

2.1: piperidine; pyridine / 75 - 120 °C

2.2: pH ~ 4

3.1: N,N-dimethyl-formamide / 0.75 h / 20 °C

4.1: N,N-dimethyl-formamide / 20 °C

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 110 - 120 °C

6.1: tin(ll) chloride / ethyl acetate / 20 °C

6.2: pH 11

7.1: pyridine / dichloromethane / 20 °C

8.1: boron tribromide / dichloromethane / -78 - 20 °C

9.1: methanol / dichloromethane / 0 - 20 °C

9.2: 0 °C / pH 8

With piperidine; pyridine; ammonium nitrate; methanol; boron tribromide; 1,1'-carbonyldiimidazole; trifluoroacetic anhydride; tin(ll) chloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 2.1: Knoevenagel Condensation;

Reference yield:

: 31680-08-7
4-methoxy-3-nitrobenzaldehyde

: 1332498-30-2
N-{2-hydroxy-5-[2-(3-propyl-[1,2,4]oxadiazol-5-yl)-vinyl]-phenyl}-methane sulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: piperidine; pyridine / 75 - 120 °C

1.2: pH ~ 4

2.1: N,N-dimethyl-formamide / 0.75 h / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 110 - 120 °C

5.1: tin(ll) chloride / ethyl acetate / 20 °C

5.2: pH 11

6.1: pyridine / dichloromethane / 20 °C

7.1: boron tribromide / dichloromethane / -78 - 20 °C

8.1: methanol / dichloromethane / 0 - 20 °C

8.2: 0 °C / pH 8

With piperidine; pyridine; methanol; boron tribromide; 1,1'-carbonyldiimidazole; tin(ll) chloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Knoevenagel Condensation;