2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole

Base Information

Chemical Name:2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole
CAS No.:1403674-84-9
Molecular Formula:C₂₈H₂₇F₂NO₃
Molecular Weight:463.524
Hs Code.:

Synonyms:2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole

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Chemical Property of 2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole

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Technology Process of 2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole

There total 4 articles about 2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 107-10-8,42939-71-9
propylamine

: 1403674-72-5
1,4-bis(2-fluoro-4-methoxyphenyl)-2-(4-methoxyphenyl)butane-1,4-dione

: 1403674-84-9
2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; for 48h; Reflux;
DOI:10.1021/jm300860j

Reference yield:

: 456-49-5
1-fluoro-3-methoxybenzene

: 1403674-84-9
2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1 h / -78 °C

2.2: -78 - 20 °C

3.1: toluene-4-sulfonic acid / ethanol / 48 h / Reflux

With aluminum (III) chloride; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene; 1.1: |Friedel-Crafts Acylation;
DOI:10.1021/jm300860j

Reference yield:

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 1403674-84-9
2,5-bis(2-fluoro-4-methoxyphenyl)-3-(4-methoxyphenyl)-1-propyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C

2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1 h / -78 °C

2.2: -78 - 20 °C

3.1: toluene-4-sulfonic acid / ethanol / 48 h / Reflux

With aluminum (III) chloride; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene; 1.1: |Friedel-Crafts Acylation;
DOI:10.1021/jm300860j