Technology Process of benzoic acid 4-dimethylamino-2-(4-ethyl-7-fluoro-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-11-prop-2-ynyloxy-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester
There total 4 articles about benzoic acid 4-dimethylamino-2-(4-ethyl-7-fluoro-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-11-prop-2-ynyloxy-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite
2.1: potassium tert-butylate; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran
3.1: hydrogenchloride; water / ethanol
4.1: N-chloro-succinimide; dimethylsulfide; triethylamine / tetrahydrofuran
5.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C
5.2: 2 h / 0 °C
With
hydrogenchloride; N-chloro-succinimide; dimethylsulfide; potassium tert-butylate; ammonia; water; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium nitrite;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
4.1: Corey-Kim oxidation;
DOI:10.1016/j.bmcl.2012.06.092
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dmap; triethylamine / ethyl acetate
2.1: potassium tert-butylate / tetrahydrofuran; dimethyl sulfoxide
3.1: hydrogenchloride; sodium nitrite
4.1: potassium tert-butylate; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran
5.1: hydrogenchloride; water / ethanol
6.1: N-chloro-succinimide; dimethylsulfide; triethylamine / tetrahydrofuran
7.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C
7.2: 2 h / 0 °C
With
hydrogenchloride; dmap; N-chloro-succinimide; dimethylsulfide; potassium tert-butylate; ammonia; water; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium nitrite;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
6.1: Corey-Kim oxidation;
DOI:10.1016/j.bmcl.2012.06.092
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-chloro-succinimide; dimethylsulfide; triethylamine / tetrahydrofuran
2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C
2.2: 2 h / 0 °C
With
N-chloro-succinimide; dimethylsulfide; sodium hydride; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: Corey-Kim oxidation;
DOI:10.1016/j.bmcl.2012.06.092
