(4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁴⁾,4,8,10,12,16,20,22-octaene

Base Information

• Chemical Name: (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁴⁾,4,8,10,12,16,20,22-octaene
• CAS No.: 211758-87-1
• Molecular Formula: C₃₀H₃₄N₂O₄S
• Molecular Weight: 518.677

Synonyms:(4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁴⁾,4,8,10,12,16,20,22-octaene

Chemical Property of (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁴⁾,4,8,10,12,16,20,22-octaene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁴⁾,4,8,10,12,16,20,22-octaene

There total 14 articles about (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁴⁾,4,8,10,12,16,20,22-octaene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-nitropyridine N-oxide (5470-66-6) → (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.08,13]tetracosa-1(24),4,8,10,12,16,20,22-octaene (211758-87-1)

Guidance literature:

Multi-step reaction with 10 steps

1: 84 percent / PCl₃ / CHCl₃ / 40 h / Ambient temperature

2: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

3: 83 percent / methanol / Ambient temperature

4: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.83 h / Ambient temperature

5: 99 percent / Na/Hg, NaH₂PO₄ / methanol / 1 h

6: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 30 min

8: 96 percent / ammonium molybdate, aq. H₂O₂ / ethanol / 17 h

9: 94 percent / aq. HCl / tetrahydrofuran / 8 h / Ambient temperature

10: 1.) LiCl, MsCl, 2,6-lutidine, 2.) NaHMDS / 1.) DMF, room temp., 2 h, 2.) THF, reflux, 2.5 h

With 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; sodium dihydrogenphosphate; sodium amalgam; n-butyllithium; ammonium molybdate; dihydrogen peroxide; sodium hexamethyldisilazane; methanesulfonyl chloride; lithium chloride; phosphorus trichloride; In tetrahydrofuran; methanol; ethanol; hexane; chloroform; dimethyl sulfoxide;

DOI:10.1021/jo9801770

Reference yield:

2-methyl-4-nitro-pyridine (13508-96-8) → (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.08,13]tetracosa-1(24),4,8,10,12,16,20,22-octaene (211758-87-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

2: 83 percent / methanol / Ambient temperature

3: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.83 h / Ambient temperature

4: 99 percent / Na/Hg, NaH₂PO₄ / methanol / 1 h

5: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 30 min

7: 96 percent / ammonium molybdate, aq. H₂O₂ / ethanol / 17 h

8: 94 percent / aq. HCl / tetrahydrofuran / 8 h / Ambient temperature

9: 1.) LiCl, MsCl, 2,6-lutidine, 2.) NaHMDS / 1.) DMF, room temp., 2 h, 2.) THF, reflux, 2.5 h

With 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; sodium dihydrogenphosphate; sodium amalgam; n-butyllithium; ammonium molybdate; dihydrogen peroxide; sodium hexamethyldisilazane; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; methanol; ethanol; hexane; dimethyl sulfoxide;

DOI:10.1021/jo9801770

Reference yield:

3-Benzenesulfonylmethyl-2-methyl-4-nitro-pyridine (88912-66-7) → (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.08,13]tetracosa-1(24),4,8,10,12,16,20,22-octaene (211758-87-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 83 percent / methanol / Ambient temperature

2: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.83 h / Ambient temperature

3: 99 percent / Na/Hg, NaH₂PO₄ / methanol / 1 h

4: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 30 min

6: 96 percent / ammonium molybdate, aq. H₂O₂ / ethanol / 17 h

7: 94 percent / aq. HCl / tetrahydrofuran / 8 h / Ambient temperature

8: 1.) LiCl, MsCl, 2,6-lutidine, 2.) NaHMDS / 1.) DMF, room temp., 2 h, 2.) THF, reflux, 2.5 h

With 2,6-dimethylpyridine; hydrogenchloride; sodium dihydrogenphosphate; sodium amalgam; n-butyllithium; ammonium molybdate; dihydrogen peroxide; sodium hexamethyldisilazane; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; methanol; ethanol; hexane;

DOI:10.1021/jo9801770

upstream raw materials:

(Z)-5-{2-[(Z)-6-(2-Benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-en-1-ol

2,2-Dimethyl-propionic acid (Z)-5-{2-[(Z)-6-(2-benzenesulfonylmethyl-4-methoxy-pyridin-3-yl)-hex-3-enyl]-4-methoxy-pyridin-3-yl}-pent-2-enyl ester

2-methyl-4-nitro-pyridine

2-methyl-4-nitropyridine N-oxide

Downstream raw materials:

7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁰⁾,8⁽¹³⁾,9,11,21,23-hexaene

7-Allyl-7-benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁰⁾,8⁽¹³⁾,9,11,21,23-hexaene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 211758-87-1 (4Z,16Z)-7-Benzenesulfonyl-12,24-dimethoxy-9,21-diaza-tricyclo[18.4.0.0^8,13]tetracosa-1⁽²⁴⁾,4,8,10,12,16,20,22-octaene

Send

Send

Metric Ton KG G Pound L ML

Send

Send