N⁴-Benzoyl-N¹-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene

Base Information

• Chemical Name: N⁴-Benzoyl-N¹-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene
• CAS No.: 124400-42-6
• Molecular Formula: C₂₄H₂₂N₂O₇S
• Molecular Weight: 482.514

Synonyms:N⁴-Benzoyl-N¹-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene

Chemical Property of N⁴-Benzoyl-N¹-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene

Chemical Property:

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Technology Process of N⁴-Benzoyl-N¹-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene

There total 4 articles about N⁴-Benzoyl-N¹-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N4-Benzoyl-N1-(phenylsulfonyl)-p-benzoquinone Diimine (124400-30-2) + malonic acid dimethyl ester (108-59-8) → N4-Benzoyl-N1-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene (124400-42-6)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 0 ℃; for 6h;

DOI:10.1021/jo00291a059

Reference yield:

p-nitrobenzanilide (3393-96-2) → N4-Benzoyl-N1-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene (124400-42-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 25 °C / 2585.7 Torr

2: 84 percent / pyridine / tetrahydrofuran / 8 h / Heating

3: 79 percent / lead tetraacetate / CHCl₃ / 12 h / 25 °C

4: 81 percent / sodium methoxide / tetrahydrofuran / 6 h / 0 °C

With pyridine; lead(IV) acetate; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; chloroform; ethyl acetate;

DOI:10.1021/jo00291a059

Reference yield:

N-(4-aminophenyl)benzamide (17625-83-1) → N4-Benzoyl-N1-(phenylsulfonyl)-1,4-diamino-3-(1,1-bis(methoxycarbonyl)methyl)benzene (124400-42-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / pyridine / tetrahydrofuran / 8 h / Heating

2: 79 percent / lead tetraacetate / CHCl₃ / 12 h / 25 °C

3: 81 percent / sodium methoxide / tetrahydrofuran / 6 h / 0 °C

With pyridine; lead(IV) acetate; sodium methylate; In tetrahydrofuran; chloroform;

DOI:10.1021/jo00291a059

upstream raw materials:

N⁴-Benzoyl-N¹-(phenylsulfonyl)-p-benzoquinone Diimine

malonic acid dimethyl ester

N-(4-aminophenyl)benzamide

p-nitrobenzanilide

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