diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate

Base Information

Chemical Name:diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate
CAS No.:1178980-70-5
Molecular Formula:C₁₉H₃₀F₂NO₆P
Molecular Weight:437.421
Hs Code.:

Synonyms:diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate

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Technology Process of diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate

There total 1 articles about diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1178980-58-9
diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-4-([tert-butyl(dimethyl)silyl]oxy)-1,1-difluoro-4-phenylbutylphosphonate

: 1178980-70-5
diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1.25h;
DOI:10.1021/jo9008782

Reference yield: 69.0%

: 1178980-70-5
diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate

: 112-67-4
n-hexadecanoyl chloride

: 528523-57-1
diethyl (3R,4S)-1,1-difluoro-4-hydroxy-3-([pentadecylcarbonyl]amino)-4-phenylbutylphosphonate

Guidance literature:: diethyl (3R,4S)-3-[(tert-butoxycarbonyl)amino]-1,1-difluoro-4-hydroxy-4-phenylbutylphosphonate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

n-hexadecanoyl chloride; With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo9008782