6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Base Information Edit

Chemical Name:6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one
CAS No.:1255701-55-3
Molecular Formula:C₁₅H₁₅N₃O₂S
Molecular Weight:301.369
Hs Code.:
Mol file:1255701-55-3.mol

Synonyms:6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

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Chemical Property of 6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one Edit

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Technology Process of 6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

There total 2 articles about 6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1255701-56-4
4-(2-(methylamino)-1-phenylethoxy)-2-(methylthio)pyrimidine-5-carboxylic acid

: 1255701-55-3
6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 30 ℃;

Reference yield:

: 77184-09-9
N-(β-Hydroxyphenaethyl)-N-methyl-carbaminsaeure-(t-butyl)ester

: 1255701-55-3
6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / -78 - 0 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C

3.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 30 °C

With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;