(2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 77184-09-9
• Molecular Formula: C14H21NO3
• Molecular Weight: 251.326
• Hs Code.: 2924299090
• Mol file: 77184-09-9.mol

Synonyms:tert-Butyl (2-hydroxy-2-phenylethyl)(methyl)carbamate;(2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER;

Chemical Property of (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• PSA: 49.77000
• LogP: 2.58690

Purity/Quality:

97% ^*data from raw suppliers

(2-Hydroxy-2-phenyl-ethyl)-methyl-carbamicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER

There total 6 articles about (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(methylamino)-1-phenylethanol (68579-60-2,6589-55-5) + di-tert-butyl dicarbonate (24424-99-5) → N-(β-Hydroxyphenaethyl)-N-methyl-carbaminsaeure-(t-butyl)ester (77184-09-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1002/hlca.200790144

Reference yield: 45.0%

benzaldehyde (100-52-7) + tert-butyl N-methyl-N-(tosylmethyl)carbamate (189809-03-8) → N-(β-Hydroxyphenaethyl)-N-methyl-carbaminsaeure-(t-butyl)ester (77184-09-9)

Guidance literature:

With naphthalene; lithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1055/s-1997-6111

Reference yield:

N-(tert-butoxycarbonyl)methylamine (16066-84-5) → N-(β-Hydroxyphenaethyl)-N-methyl-carbaminsaeure-(t-butyl)ester (77184-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄, Me₃SiCl / benzene / 3 h / Ambient temperature

2: 1.) Li, 4,4'-di-tert-butylbiphenyl, 2.) H₂O / 1.) THF, -78 deg C, 2 h

With chloro-trimethyl-silane; 4,4'-di-tert-butylbiphenyl; water; lithium; magnesium sulfate; In benzene;

DOI:10.1016/S0040-4020(99)00155-6

upstream raw materials:

2-(methylamino)-1-phenylethanol

di-tert-butyl dicarbonate

O-tert-butyl-N-(chloromethyl)-N-methyl carbamate

benzaldehyde

Downstream raw materials:

ethyl 4-(2-(tert-butoxycarbonyl(methyl)amino)-1-phenylethoxy)-2-(methylthio)pyrimidine-5-carboxylate

2-(4-(1H-imidazol-1-yl)phenoxy)-6-methyl-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

6-methyl-2-(methylsulfonyl)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

4-(2-(methylamino)-1-phenylethoxy)-2-(methylthio)pyrimidine-5-carboxylic acid