77184-09-9

Basic information

• Product Name: (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER;tert-Butyl (2-hydroxy-2-phenylethyl)(methyl)carbamate;2-(N-Boc-N-methylamino)-1-phenylethanol
• CAS NO: 77184-09-9
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.32
• Mol File: 77184-09-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER(77184-09-9)
• EPA Substance Registry System: (2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER(77184-09-9)

Safety Data

• Hazardous Substances Data: 77184-09-9(Hazardous Substances Data)

Usage

General Description

(2-HYDROXY-2-PHENYL-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER, also known as tioconazole, is a synthetic antifungal medication used to treat vaginal yeast infections. It works by inhibiting the growth of fungi, specifically Candida species, which are responsible for causing the infection. Tioconazole is available in various forms such as creams, ointments, and suppositories for vaginal administration. It is generally well-tolerated and effective in treating yeast infections, with minimal side effects. However, individuals with a known allergy to tioconazole or related compounds should avoid using this medication. Overall, tioconazole is an important tool in the treatment of fungal infections and offers relief to those suffering from the discomfort and itching associated with yeast infections.

Upstream product

• 39073-23-9 O-tert-butyl-N-(chloromethyl)-N-methyl carbamate 
• 100-52-7 benzaldehyde 
• 189809-03-8 tert-butyl N-methyl-N-(tosylmethyl)carbamate 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 73286-37-0 N-(2-oxo-2-phenylethyl)formamide 
• 16066-84-5 N-(tert-butoxycarbonyl)methylamine 
• 68579-60-2 2-(methylamino)-1-phenylethanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 68579-60-2 2-(methylamino)-1-phenylethanol 
• 1255701-57-5 ethyl 4-(2-(tert-butoxycarbonyl(methyl)amino)-1-phenylethoxy)-2-(methylthio)pyrimidine-5-carboxylate 
• 1255701-55-3 6-methyl-2-(methylthio)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1255701-56-4 4-(2-(methylamino)-1-phenylethoxy)-2-(methylthio)pyrimidine-5-carboxylic acid 
• 1255701-54-2 6-methyl-2-(methylsulfonyl)-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1255700-55-0 2-(4-(1H-imidazol-1-yl)phenoxy)-6-methyl-8-phenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 77184-12-4 rac-3-hydroxy-1-methyl-3-phenylazetidin-2-one 
• 76467-28-2 N-Methyl-N-phenacylformamid 
• 6853-14-1 2-dimethylamino-1-phenylethanol 
• 77184-10-2 1,1-dimethylethyl methyl(2-phenyl-2-oxoethyl)carbamate 

Relevant articles and documents

NEW COMPOUNDS MODULATING GAMMA-SECRETASE AND THEIR USE IN THE TREATMENT OF ALPHA BETA RELATED PATHOLOGIES, SUCH AS ALZHEIMER'S DISEASE

The present invention relates to novel compounds of formulae (I) and (II) and therapeutically acceptable salts thereof, their pharmaceutical compositions processes for making them and their use in therapeutic methods for treatment and/or prevention of var

α-Aminated methyllithium by DTBB-catalysed lithiation of a N- (chloromethyl) carbamate

The reaction of O-tert-butyl-N-(chloromethyl)-N-methyl carbamate (1) with lithium powder and a catalytic amount of 4,4'-di-tert-butylbiphenyl (DTBB, 2.5 mol %) in the presence of different electrophiles [Me3SiCl, (i)BuCHO, (t)BuCHO, PhCHO, 4-MeOC6H4CHO, (CH2)4CO, MeCO(n)Pr, Et2CO, MeCO(CH2)2CH=CH2, PhCOMe, PhCO(n)Bu, Ph2CO] in THF at -78°C leads, after hydrolysis with water, to the expected functionalised carbamates 2. Carbamates 2 derived from carbonyl compounds are deprotected with hydrogen chloride (for aromatic aldehyde or ketone derivatives) or with a mixture of phenol and trimethylsilyl chloride (for aliphatic aldehyde derivatives) giving substituted 1,2-diols 4.

α-Nitrogenated organolithium compounds from α-amidomethyl and α-aminomethyl sulfones

Successive reaction of α-amidomethyl sulfones 7a,b, derived from primary amides, with n-butyllithium and primary alkyl bromides (CH2 = CHCH2Br, CH2 = CMeCH2Br, CH2 = CBrCH2Br, CH ≡ CCH