methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate

Base Information

Chemical Name:methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate
CAS No.:1620517-25-0
Molecular Formula:C₂₁H₂₁N₃O₄
Molecular Weight:379.415
Hs Code.:

Synonyms:methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate

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Technology Process of methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate

There total 7 articles about methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1501-27-5
Pentanedioic acid, monomethyl ester

: 775302-21-1
3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)aniline

: 1620517-25-0
methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate

Guidance literature:: With 3-Methylpyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1620517-22-7
C₂₀H₁₉N₃O₄

: 74-88-4
methyl iodide

: 1620517-25-0
methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 20h;
DOI:10.1016/j.ejmech.2014.06.011

Reference yield:

: 618-95-1
methyl 3-nitrobenzoate

: 1620517-25-0
methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / 6 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 3-Methylpyridine / dichloromethane / 12 h / 20 °C

3: trichlorophosphate / acetonitrile / 8 h / Reflux

4: hydrogen / methanol; tetrahydrofuran / 20 °C / 760.05 Torr

5: triethylamine / tetrahydrofuran / 20 °C

6: potassium carbonate / acetone / 20 h / 20 °C

With 3-Methylpyridine; hydrogen; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2014.06.011