N4-ACETYL-2'-DEOXYCYTIDINE

Base Information

• Chemical Name: N4-ACETYL-2'-DEOXYCYTIDINE
• CAS No.: 32909-05-0
• Molecular Formula: C11H15 N3 O5
• Molecular Weight: 269.257
• Mol file: 32909-05-0.mol

Synonyms:Acetamide,N-[1-(2-deoxy-b-D-erythro-pentofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]-(8CI); 2'-Deoxy-N-acetylcytidine; N-Acetyldeoxycytidine;N4-Acetyl-2'-deoxycytidine; N4-Acetyldeoxycytidine

Chemical Property of N4-ACETYL-2'-DEOXYCYTIDINE

Chemical Property:

• Melting Point: 150-152 °C
• PKA: 10.28±0.20(Predicted)
• PSA: 113.68000
• Density: 1.6g/cm3
• LogP: -1.08460
• Storage Temp.: Store at 0°C
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly

Purity/Quality:

98%, ^*data from raw suppliers

Adiponectin, Human ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Human ADIPOQ / Adiponectin ELISA Kit has been used in the quantification of leptin and adiponectin from serum and plasma samples.

Technology Process of N4-ACETYL-2'-DEOXYCYTIDINE

There total 8 articles about N4-ACETYL-2'-DEOXYCYTIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + 2'-Deoxycytidine (951-77-9) → N4-acetyl-2'-deoxycytidine (32909-05-0)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1080/07328319708006236

Reference yield: 98.0%

→ N4-acetyl-2'-deoxycytidine (32909-05-0)

Guidance literature:

Reference yield: 80.0%

acetic acid (64-19-7,77671-22-8) + 2'-Deoxycytidine (951-77-9) → N4-acetyl-2'-deoxycytidine (32909-05-0)

Guidance literature:

acetic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In dichloromethane; at 20 ℃;

2'-Deoxycytidine; In dichloromethane; N,N-dimethyl-formamide; at 20 - 50 ℃;

DOI:10.5012/bkcs.2010.31.7.2061

upstream raw materials:

N⁴-acetyl-1-<2'-deoxy-3',5'-di-O-acetyl-β-D-ribofyranosyl>cytosine

acetic anhydride

2'-Deoxycytidine

S-(1,2-Dichlorovinyl)thioacetate

Downstream raw materials:

2'-deoxy-N⁴-ethyl-cytidine

5’-O-(4,4’dimethoxytrityl)-N4-(acetyl)-2'-deoxycytidine

C₃₂H₃₁N₃O₆

5'-PhSNPPOC-dC(Ac)

Refernces

• 1、 Rode, Ambadas B.,Son, Sang Jun,Hong, In Seok. "An efficient one-pot N-acylation of deoxy- and ribo-cytidine using carboxylic acids activated in situ with 2-chloro-4,6-dimethoxy-1,3,5-triazine". experimental part. p. 2061 - 2064. Retrieved 2010/11/19.
• 2、 -. "CAC H-phosphonate and its use in the synthesis of oligonucleotides". . . Retrieved 2008/06/13.