3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide

Base Information

Chemical Name:3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide
CAS No.:1124215-38-8
Molecular Formula:C₂₆H₃₅FN₄O₂
Molecular Weight:454.588
Hs Code.:

Synonyms:3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide

Chemical Property:

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Technology Process of 3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide

There total 8 articles about 3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124215-36-6
N-tert-butyl-3-(2-methyl-1-(piperazin-1-yl)propyl)benzamide

: 455-87-8
4-amino-3-fluorobenzoic acid

: 1124215-38-8
3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 1124215-36-6
N-tert-butyl-3-(2-methyl-1-(piperazin-1-yl)propyl)benzamide

: 455-87-8
4-amino-3-fluorobenzoic acid

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 1124215-38-8
3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In dichloromethane; ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 1124215-27-5
3-(1-hydroxy-2-methylpropyl)benzonitrile

: 1124215-38-8
3-(1-(4-(4-amino-3-fluorobenzoyl)piperazin-1-yl)-2-methylpropyl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / ethanol / 0.17 h / 160 °C / microwave irradiation

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 100 °C / microwave irradiation

3: dichloromethane / 1.5 h

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / microwave irradiation

5: hydrogenchloride / 1,4-dioxane / 0.5 h / 80 °C

6: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 2 h / 20 °C

With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;