triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

Base Information

Chemical Name:triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane
CAS No.:1376185-61-3
Molecular Formula:C₁₇H₃₀OSi
Molecular Weight:278.51
Hs Code.:

Synonyms:triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

Suppliers and Price of triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

There total 10 articles about triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 994-30-9
triethylsilyl chloride

: 118829-40-6,118829-45-1
(R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-ol

: 1376185-61-3
triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.75h; stereoselective reaction; Inert atmosphere;
DOI:10.1039/c2ob25321f

Reference yield:

: 20548-02-1,55058-51-0,60686-81-9,60686-82-0,82977-53-5,90082-06-7,90129-05-8,99881-84-2,60046-50-6
(4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexan-1-one

: 1376185-61-3
triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

Guidance literature:: Multi-step reaction with 7 steps

1: dmap; triethylamine / dichloromethane / 0 °C

2: n-butyllithium / tetrahydrofuran / -50 °C

3: potassium hydroxide / methanol; water / 20 °C

4: pyridine / 20 °C

5: copper(II) sulfate / 5,5-dimethyl-1,3-cyclohexadiene / Reflux

6: lithium aluminium tetrahydride / diethyl ether / 0.25 h / 0 °C / Inert atmosphere

7: dmap; triethylamine / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; lithium aluminium tetrahydride; n-butyllithium; copper(II) sulfate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; dichloromethane; water;
DOI:10.1039/c2ob25321f

Reference yield:

: 152125-31-0
(4R,6R)-2,2,6-Trimethyl-4-trimethylsilanyloxy-cyclohexanone

: 1376185-61-3
triethyl[(4R)-4-ethynyl-3,5,5-trimethylcyclohex-3-en-1-yl]-oxysilane

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / tetrahydrofuran / -50 °C

2: potassium hydroxide / methanol; water / 20 °C

3: pyridine / 20 °C

4: copper(II) sulfate / 5,5-dimethyl-1,3-cyclohexadiene / Reflux

5: lithium aluminium tetrahydride / diethyl ether / 0.25 h / 0 °C / Inert atmosphere

6: dmap; triethylamine / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; lithium aluminium tetrahydride; n-butyllithium; copper(II) sulfate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; dichloromethane; water;
DOI:10.1039/c2ob25321f