Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate

Base Information

Chemical Name:Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate
CAS No.:1192040-53-1
Molecular Formula:C₂₂H₂₂F₃NO₃
Molecular Weight:405.417
Hs Code.:

Synonyms:Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate

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Chemical Property of Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate

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Technology Process of Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate

There total 4 articles about Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 480-91-1
oxisoindole

: 1192039-83-0
ethyl 2-[4-(bromomethyl)phenyl]-4,4,4-trifluoro-3-methylbutanoate

: 1192040-53-1
Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate

Guidance literature:: oxisoindole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

ethyl 2-[4-(bromomethyl)phenyl]-4,4,4-trifluoro-3-methylbutanoate; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

Reference yield:

: 106-38-7
para-bromotoluene

: 1192040-53-1
Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / DavePhos; palladium diacetate / toluene / -10 °C / Inert atmosphere

1.2: 20 - 80 °C

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 2 h / 0 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; lithium hexamethyldisilazane; palladium diacetate; DavePhos; In chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6975-13-9
(+/-)-ethyl 4,4,4-trifluoro-3-methylbutanoate

: 1192040-53-1
Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / DavePhos; palladium diacetate / toluene / -10 °C / Inert atmosphere

1.2: 20 - 80 °C

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 2 h / 0 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; lithium hexamethyldisilazane; palladium diacetate; DavePhos; In chloroform; N,N-dimethyl-formamide; toluene;