6975-13-9

Usage

Uses

Used in Pharmaceutical Industry:
NSC 22077 is used as an anti-cancer agent for its ability to inhibit the growth and survival of cancer cells by targeting the protein kinase AKT. This makes it a potential candidate for cancer therapy, particularly in the treatment of various malignancies.
Used in Anti-inflammatory Applications:
NSC 22077 is used as an anti-inflammatory agent for its capacity to reduce the production of pro-inflammatory cytokines. This property can be beneficial in managing inflammation-related conditions and diseases.
Used in Research and Development:
NSC 22077 is used as a research tool for studying the role of protein kinase AKT in cell growth, survival, and metabolism. Its inhibitory effects on AKT can provide valuable insights into the development of novel therapeutic strategies for cancer and inflammatory disorders.

InChI:InChI=1/C7H11F3O2/c1-3-12-6(11)4-5(2)7(8,9)10/h5H,3-4H2,1-2H3/t5-/m0/s1

Upstream product

• 623-70-1 ethyl (E)-crotonate 
• 76-05-1 trifluoroacetic acid 
• 691-77-0 (E)-3-trifluoromethyl-2-butenoic acid ethyl ester 
• 93404-33-2 3-trifluoromethyl-2-butenoic acid 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 64-17-5 ethanol 
• 348-75-4 (-)-3-trifluoromethylbutanoic acid 

Downstream Products

• 339-62-8 (+/-)-4,4,4-Trifluor-3-methyl-1-butanol 
• 95853-72-8 (R)-(+)-4,4,4-Trifluor-3-methylbutyl-(p-toluolsulfonat) 
• 95853-69-3 (+/-)-4,4,4-Trifluor-3-methyl-1-butanal 
• 95853-77-3 (2S,4R)-(+)-5,5,5-Trifluor-2-<(1S,2S)-(2-hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-4-methylvaleriansaeure 
• 95911-01-6 (2R,4R)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril 
• 95853-76-2 (2S,4R)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-5,5,5-trifluor-4-methylvaleronitril 
• 794568-87-9 rac-1-(2-methylphenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 862646-44-4 N-[4-chloro-2-(4,4,4-trifluoro-3-methylbutyryl)-phenyl]-2,2-dimethylpropionamide 
• 1192039-73-8 ethyl 4,4,4-trifluoro-3-methyl-2-(4-methylphenyl)butanoate 
• 1192039-83-0 ethyl 2-[4-(bromomethyl)phenyl]-4,4,4-trifluoro-3-methylbutanoate 
• 1192040-53-1 Ethyl 4,4,4-trifluoro-3-methyl-2-{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-butanoate 

Relevant academic research and scientific papers

Diastereoselectivity of enolate anion protonation. H/D exchange of β-substituted ethyl butanoates in ethanol-d

The stereochemistry of base-catalyzed H/D exchange on 13 β-substituted ethyl butanoates in ethanol-d has been studied in order to analyze the steric and electronic factors which control the diastereoselectivity of electrophilic attack on enolate anions. E

Nonproteinogenic Amino Acids, II. - Synthesis and Determination of the Absolute Configuration of (2S,4S)-(-)- and (2S,4R)-(+)-5,5,5-Trifluoroleucine

The synthesis (Scheme 1) of racemic 4,4,4-trifluoro-3-methyl-1-butanol (5) and the resolution of its enantiomers is described.The absolute configuration of the negatively rotating enantiomer of 5 is correlated to that of the optically active fermentation amyl alcohol (S-10) via (S)-(-)-1,1,1-trifluoro-2-methylbutane (S-8) (Scheme 2).Oxidation of optically pure (R)-(+)-4,4,4-trifluoro-3-methyl-1-butanol (R-5) yields the aldehyde R-6 which is employed as starting material for the asymmetric Strecker synthesis of (2S,4R)-(+)-5,5,5-trifluoroleucine (13a).The analogous synthesis with (+/-)-4,4,4-trifluoro-3-methyl-1-butanol (6) via the aminonitrile 11 affords the optically pure (2S,4S)-diastereoisomer 11b which leads to enantiomerically pure (2S,4S)-(-)-5,5,5-trifluoroleucine (13b).

ASYMMETRICAL REDUCTION OF PERFLUOROALKYLATED KETONES, KETOESTERS AND VINYL COMPOUNDS WITH BAKER'S YEAST

Reduction of perfluoroalkylated ketones, ketoesters and vinyl compounds with baker's yeast was studied.The ketones and β-ketoesters were asymmetrically reduced to give optically active perfluoroalkylated carbinols and hydroxyesters, while the vinyl compounds were reduced to perfluoroalkylated alkanes.