1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

Base Information

Chemical Name:1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one
CAS No.:1398608-92-8
Molecular Formula:C₂₄H₁₆Cl₃F₃N₂O₄
Molecular Weight:559.756
Hs Code.:

Synonyms:1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

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Chemical Property of 1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

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Technology Process of 1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

There total 10 articles about 1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1398609-67-0
5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1398608-92-8
1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

Guidance literature:: 5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

cyclopropanecarboxylic acid chloride; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: 1357614-71-1
3-(3-bromo-4-iodophenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

: 1398608-92-8
1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 0 - 40 °C / Inert atmosphere

1.2: 2.5 h / -40 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

3.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane; acetonitrile / 20 h / 0 - 20 °C / Reflux

3.2: 1 h / Reflux

4.1: triethylamine / dichloromethane / 0.08 h / 20 °C

4.2: 0.25 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; isopropylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1357614-73-3
1-benzhydryl-3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

: 1398608-92-8
1-(cyclopropanecarbonyl)-5'-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro{azetidine-3,1'-isobenzofuran}-3'-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane; acetonitrile / 20 h / 0 - 20 °C / Reflux

2.2: 1 h / Reflux

3.1: triethylamine / dichloromethane / 0.08 h / 20 °C

3.2: 0.25 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;