tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate
CAS No.:840531-30-8
Molecular Formula:C₂₃H₂₈N₄O₆
Molecular Weight:456.499
Hs Code.:

Synonyms:tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate

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Chemical Property of tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate

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Technology Process of tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate

There total 1 articles about tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 303134-14-7
4-[4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl]benzoic acid

: 603-85-0
2-Amino-3-nitrophenol

: 840531-30-8
tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate

Guidance literature:: 4-[4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl]benzoic acid; With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.0833333h;

2-Amino-3-nitrophenol; With pyridine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2004.11.005

Reference yield: 91.0%

: 840531-30-8
tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate

: 105-36-2
ethyl bromoacetate

: 840531-32-0
tert-butyl 4-[4-({[2-(2-ethoxy-2-oxoethoxy)-6-nitrophenyl]amino}carbonyl)phenyl]-1,4-diazepane-1-carboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2004.11.005

Reference yield:

: 840531-30-8
tert-butyl 4-(4-{[(2-hydroxy-6-nitrophenyl)amino]carbonyl}phenyl)-1,4-diazepane-1-carboxylate

: 840531-41-1
ethyl (3-({3-[amino(imino)methyl]benzoyl}amino)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / potassium carbonate / acetonitrile / 48 h / 20 °C

2: Fe; ammonium chloride / ethanol; H₂O / 0.5 h / Heating

3: pyridine / 20 h / 20 °C

4: HCl / ethyl acetate / 2 h / 20 °C

5: 2.508 g / sodium triacetoxyborohydride; acetic acid / 1,2-dichloro-ethane; H₂O / 2 h / 20 °C

6: HCl / CHCl₃ / 24 h / 5 °C

7: ammonium acetate / ethanol / 36 h / 20 °C

With pyridine; ammonium acetate; hydrogenchloride; ammonium chloride; sodium tris(acetoxy)borohydride; iron; potassium carbonate; acetic acid; In ethanol; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile; 6: Pinner reaction;
DOI:10.1016/j.bmc.2004.11.005