AKOS B018302

Base Information

• Chemical Name: AKOS B018302
• CAS No.: 349-33-7
• Molecular Formula: C10H6 F N O S2
• Molecular Weight: 239.294
• Hs Code.: 2934999090
• Mol file: 349-33-7.mol

Synonyms:CHEMBRDG-BB 3018302;ART-CHEM-BB B018302;AKOS B018302;(5E)-5-(3-fluorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one

Chemical Property of AKOS B018302

Chemical Property:

• Vapor Pressure: 2.17E-05mmHg at 25°C
• Refractive Index: 1.706
• Boiling Point: 360.7°C at 760 mmHg
• Flash Point: 172°C
• PSA: 93.53000
• Density: 1.5g/cm³
• LogP: 2.16140
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(5E)-5-(3-Fluorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B018302

There total 2 articles about AKOS B018302 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-thioxo-4-thiazolidinone (141-84-4) + 3-Fluorobenzaldehyde (456-48-4) → (5Z)-5-(3-fluorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (349-33-7)

Guidance literature:

With sodium acetate; In acetic acid; at 110 ℃; for 0.266667h; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.12.113

Reference yield:

→ (5Z)-5-(3-fluorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (349-33-7)

Guidance literature:

/BRN= 176579/;

DOI:10.1021/ja01149a510

Reference yield: 90.0%

(5Z)-5-(3-fluorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (349-33-7) + methyl iodide (74-88-4) → (Z)-5-(3-fluorobenzylidene)-2-(methylthio)thiazol-4(5H)-one (1544402-04-1)

Guidance literature:

With triethylamine; In dichloromethane; at 40 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.12.113

upstream raw materials:

2-thioxo-4-thiazolidinone

3-Fluorobenzaldehyde

Downstream raw materials:

2-(2-((Z)-5-(3-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)ethyl)isoindoline-1,3-dione

(Z)-5-(3-fluorobenzylidene)-2-(methylthio)thiazol-4(5H)-one

Refernces

• 1、 Pansare, Dattatraya N.,Shinde, Devanand B.. "A facile synthesis of (Z)-5-(substituted)-2-(methylthio)thiazol-4(5H)-one using microwave irradiation and conventional method". . p. 1107 - 1110. Retrieved 2015/02/19.
• 2、 Radi, Marco,Botta, Lorenzo,Casaluce, Gianni,Bernardini, Martina,Botta, Maurizio. "Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives". experimental part. p. 200 - 205. Retrieved 2010/10/19.