2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole

Base Information

• Chemical Name: 2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole
• CAS No.: 36937-64-1
• Molecular Formula: C₁₇H₁₃BrClN₃S
• Molecular Weight: 406.733
• Mol file: 36937-64-1.mol

Synonyms:2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole

Chemical Property of 2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole

There total 2 articles about 2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.66%

2-[1-(4-bromophenyl)ethylidene]hydrazine-1-carbothioamide (16546-06-8) + 4-chlorobenzoylmethyl bromide (536-38-9) → 2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole (36937-64-1)

Guidance literature:

In ethanol; at 20 ℃; for 4h;

Reference yield:

para-bromoacetophenone (99-90-1) → 2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole (36937-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / ethanol / 4 h / Reflux

2: ethanol / Reflux

With sulfuric acid; In ethanol;

DOI:10.2174/1570178615666180425120039

Reference yield:

2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole (36937-64-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(4-bromophenyl)-1-[4-(4-chlorophenyl)thiazol-2-yl]-1H-pyrazole-4-carbaldehyde

Guidance literature:

2-(2-(1-(4-bromophenyl)ethylidene)hydrazinyl)-4-(4-chlorophenyl)thiazole; N,N-dimethyl-formamide; With trichlorophosphate; at 70 - 80 ℃; for 5h;

With water;

DOI:10.2174/1570178615666180425120039

upstream raw materials:

2-[1-(4-bromophenyl)ethylidene]hydrazine-1-carbothioamide

4-chlorobenzoylmethyl bromide

para-bromoacetophenone