16546-06-8

Basic information

• Product Name: (1E)-1-(4-bromophenyl)ethanone thiosemicarbazone
• Synonyms: hydrazinecarbothioamide, 2-[1-(4-bromophenyl)ethylidene]-, (2E)-
• CAS NO: 16546-06-8
• Molecular Formula: C₉H₁₀BrN₃S
• Molecular Weight: 272.1648
• Mol File: 16546-06-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 365.3°C at 760 mmHg
• Flash Point: 174.7°C
• Density: 1.55g/cm³
• Vapor Pressure: 1.58E-05mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: (1E)-1-(4-bromophenyl)ethanone thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-1-(4-bromophenyl)ethanone thiosemicarbazone(16546-06-8)
• EPA Substance Registry System: (1E)-1-(4-bromophenyl)ethanone thiosemicarbazone(16546-06-8)

Safety Data

• Hazardous Substances Data: 16546-06-8(Hazardous Substances Data)

Usage

General Description

(1E)-1-(4-bromophenyl)ethanone thiosemicarbazone is a chemical compound that is derived from thiosemicarbazide and 1-(4-bromophenyl)ethanone. It is a yellow crystalline solid with the molecular formula C9H10BrN3S and a molar mass of 259.16 g/mol. (1E)-1-(4-bromophenyl)ethanone thiosemicarbazone has been studied for its potential biological and pharmacological properties, including its antimicrobial, antifungal, and anticancer activities. It is also known to form complexes with various metal ions and has been investigated for its potential use in analytical chemistry and catalysis. The compound's structural and functional properties make it a subject of interest for further research in the fields of medicinal chemistry and materials science.

Upstream product

• 99-90-1 para-bromoacetophenone 
• 79-19-6 thiosemicarbazide 
• 4346-94-5 thiosemicarbazide hydrochloride 

Downstream Products

• 1389248-84-3 C₂₇H₂₃BrN₃PS 
• 1516632-30-6 1-(1-p-bromophenyl)ethylidene-2-[4-(5-methyl-1-p-tolyl-1,2,3-triazol-4-yl)thiazol-2-yl]hydrazine 

Relevant articles and documents

Synthesis, Characterization, and Anticancer Screening of Some New Bithiazole Derivatives

Abstract: Twenty new bithiazole derivatives were synthesized by condensation of2-{2-[(1-arylethylidene)hydrazinylidene]thiazolidin-4-ylidene}hydrazine-1-carbothioamideswith halo ketones, halo esters, and α-keto hydrazonoyl halides. The structuresof all pr

Microwave-assisted Vilsmeier-Haack synthesis of Pyrazole-4-carbaldehydes

The synthesis of 4-formylpyrazoles using Vilsmeier-Haack reagent is a common protocol in pyrazole chemistry. An efficient microwave-assisted synthesis of 4-formylpyrazoles by employing Vilsmeier-Haack reagent (OPC-VH) derived from phthaloyl dichloride/dimethylformamide has been described. This method offers the advantages of operational simplicity, avoiding the use of POCl3 as toxic reagents and reuse of the by-product in the preparation of phthaloyl dichloride.

Microwave-assisted synthesis and biological evaluation of pyrazole-4-carbonitriles as antimicrobial agents

An efficient microwave-assisted method of synthesis of pyrazole-4-carbonitriles has been developed. Condensation of pyrazole-4-carbaldehydes with hydroxylamine hydrochloride followed by reaction of the resulting oximes with the Vilsmeier-Haack reagent pre-formed from phthaloyl dichloride and dimethylformamide under microwave irradiation afforded the corresponding pyrazole-4-carbonitriles in 73percent to 91percent yield. The operational simplicity, avoidance of toxic reagents such as POCl3, shorter reaction time, higher yield compared to the classical version, easy work up, and the use of the by-product in the regeneration of phthaloyl dichloride are the advantages of this methodology. All the target compounds were tested for antimicrobial activity against Gram-positive bacteria Bacillus cereus and Staphylococcus aureus; Gram-negative bacteria Escherichia coli and Yersinia enterocolitica, and the fungal species Candida albicans.