6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

Base Information

• Chemical Name: 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
• CAS No.: 347-40-0
• Molecular Formula: C₉H₈F₃NO
• Molecular Weight: 203.164
• Hs Code.: 2934999090
• Mol file: 347-40-0.mol

Synonyms:6-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine

Chemical Property of 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

Chemical Property:

• PSA: 21.26000
• LogP: 2.64770
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

There total 5 articles about 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(trifluoromethyl)-2H-1,4-benzoxazin-3(4H)-one (189940-04-3) → 6-trifluoromethyl-3,4-dihydro-2H-benzo[1,4]oxazine (347-40-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; methanol;

Reference yield:

2-amino-4-(trifluoromethyl)phenol (454-81-9) + ethylene dibromide (106-93-4) → 6-trifluoromethyl-3,4-dihydro-2H-benzo[1,4]oxazine (347-40-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 125 ℃; for 15h;

DOI:10.1016/j.tetlet.2006.08.029

Reference yield:

2-nitro-4-trifluoromethylphenol (400-99-7) → 6-trifluoromethyl-3,4-dihydro-2H-benzo[1,4]oxazine (347-40-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / palladium-carbon / tetrahydrofuran / 0 - 40 °C

2: sodium hydrogencarbonate / water; ethyl acetate / 0 - 40 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 40 °C

4: borane-THF / tetrahydrofuran / 6 h / 0 - 70 °C

With borane-THF; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium-carbon; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2-amino-4-(trifluoromethyl)phenol

ethylene dibromide

6-(trifluoromethyl)-2H-1,4-benzoxazin-3(4H)-one

2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]acetamide

Refernces

• 1、 -. "Pharmaceutical Compositions Comprising Nitrogen-Containing Fused Ring Coumpounds". . . Retrieved 2009/01/20.
• 2、 -. "Nitrogen-containing fused ring compounds and use thereof". Page/Page column 103. . Retrieved 2010/11/25.