N-(p-methoxyphenyl)pent-4-enaldimine

Base Information

• Chemical Name: N-(p-methoxyphenyl)pent-4-enaldimine
• CAS No.: 286933-13-9
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 286933-13-9.mol

Synonyms:N-(p-methoxyphenyl)pent-4-enaldimine

Chemical Property of N-(p-methoxyphenyl)pent-4-enaldimine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-(p-methoxyphenyl)pent-4-enaldimine

There total 1 articles about N-(p-methoxyphenyl)pent-4-enaldimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-pentenal (2100-17-6) + 4-methoxy-aniline (104-94-9) → N-(p-methoxyphenyl)pent-4-enaldimine (286933-13-9)

Guidance literature:

4-pentenal; 4-methoxy-aniline; In diethyl ether; at 0 ℃; for 0.25h;

With potassium hydroxide; In diethyl ether; for 0.25h;

Reference yield: 56.0%

N-(p-methoxyphenyl)pent-4-enaldimine (286933-13-9) + (1R,2S)-2-phenyl-1-cyclohexyl<(triisopropylsilyl)oxy>acetate (132127-27-6) → (3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(3-butenyl)azetidin-2-one (286933-02-6)

Guidance literature:

(1R,2S)-2-phenyl-1-cyclohexyl<(triisopropylsilyl)oxy>acetate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -84 ℃;

N-(p-methoxyphenyl)pent-4-enaldimine; In tetrahydrofuran; at -84 - 20 ℃; Further stages.;

DOI:10.1021/ja000293w

Reference yield: 55.0%

N-(p-methoxyphenyl)pent-4-enaldimine (286933-13-9) + 1-nitro-1-phenylmethane (622-42-4) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(4-methoxyphenyl)-N-((1S*,2R*)-1-nitro-1-phenylhex-5-en-2-yl)acetamide

Guidance literature:

1-nitro-1-phenylmethane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

N-(p-methoxyphenyl)pent-4-enaldimine; With trifluoroacetic acid; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere; Schlenk technique;

trifluoroacetic anhydride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 25 ℃; for 18h; diastereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2018.06.022

upstream raw materials:

4-pentenal

4-methoxy-aniline

Downstream raw materials:

(3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(3-butenyl)azetidin-2-one

2-debenzoyl-2-(2-allyloxybenzoyl)-7-triethylsilyl-13-[(2R,3S)-3-tert-butoxycarbonylamino-2-triethylsiloxyhept-6-enoyl]baccatin III

C₁₆H₂₃NO