(2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol

Base Information

Chemical Name:(2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol
CAS No.:1246248-68-9
Molecular Formula:C₁₆H₂₇BrFNO₂Si
Molecular Weight:392.384
Hs Code.:

Synonyms:(2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol

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Chemical Property of (2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol

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Technology Process of (2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol

There total 5 articles about (2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246248-67-8
(2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

: 1246248-68-9
(2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol

Guidance literature:: (2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate; With potassium phtalimide; In N,N-dimethyl-formamide; at 20 - 110 ℃; for 18h;

With hydrazine hydrate; In ethanol; at 20 - 60 ℃; for 3.5h;

Reference yield:

: 1007-15-4
4-fluoro-3-bromoacetophenone

: 1246248-68-9
(2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene; tetrahydrofuran / 1 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 4 h / Cooling with ice; Reflux

2.1: boron trifluoride diethyl etherate / dichloromethane / 18 h / -5 °C / Molecular sieve

3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C / Inert atmosphere; Cooling with ice

4.1: AD mix-β / water; tert-butyl alcohol / 16 h / Cooling with ice

5.1: triethylamine / dichloromethane / 4 h / Cooling with ice; Inert atmosphere

6.1: potassium phtalimide / N,N-dimethyl-formamide / 18 h / 20 - 110 °C

6.2: 3.5 h / 20 - 60 °C

With 1H-imidazole; AD mix-β; boron trifluoride diethyl etherate; potassium phtalimide; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1246248-65-6
{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

: 1246248-68-9
(2R)-1-Amino-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: AD mix-β / water; tert-butyl alcohol / 16 h / Cooling with ice

2.1: triethylamine / dichloromethane / 4 h / Cooling with ice; Inert atmosphere

3.1: potassium phtalimide / N,N-dimethyl-formamide / 18 h / 20 - 110 °C

3.2: 3.5 h / 20 - 60 °C

With AD mix-β; potassium phtalimide; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;