(2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

Base Information

Chemical Name:(2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate
CAS No.:1246248-67-8
Molecular Formula:C₁₇H₂₈BrFO₅SSi
Molecular Weight:471.46
Hs Code.:

Synonyms:(2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of (2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

There total 5 articles about (2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246248-66-7
(2R)-2-(3-bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}butane-1,2-diol

: 124-63-0
methanesulfonyl chloride

: 1246248-67-8
(2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; for 4h; Cooling with ice; Inert atmosphere;

Reference yield:

: 1007-15-4
4-fluoro-3-bromoacetophenone

: 1246248-67-8
(2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene; tetrahydrofuran / 1 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 4 h / Cooling with ice; Reflux

2.1: boron trifluoride diethyl etherate / dichloromethane / 18 h / -5 °C / Molecular sieve

3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C / Inert atmosphere; Cooling with ice

4.1: AD mix-β / water; tert-butyl alcohol / 16 h / Cooling with ice

5.1: triethylamine / dichloromethane / 4 h / Cooling with ice; Inert atmosphere

With 1H-imidazole; AD mix-β; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol;

Reference yield:

: 1246248-65-6
{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

: 1246248-67-8
(2R)-2-(3-Bromo-4-fluorophenyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxybutyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: AD mix-β / water; tert-butyl alcohol / 16 h / Cooling with ice

2: triethylamine / dichloromethane / 4 h / Cooling with ice; Inert atmosphere

With AD mix-β; triethylamine; In dichloromethane; water; tert-butyl alcohol;