{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

Base Information

Chemical Name:{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane
CAS No.:1246248-65-6
Molecular Formula:C₁₆H₂₄BrFOSi
Molecular Weight:359.354
Hs Code.:

Synonyms:{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

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Chemical Property of {[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

Chemical Property:

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Technology Process of {[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

There total 3 articles about {[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1246248-64-5
3-(3-Bromo-4-fluorophenyl)but-3-en-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1246248-65-6
{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere; Cooling with ice;

Reference yield:

: 1007-15-4
4-fluoro-3-bromoacetophenone

: 1246248-65-6
{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene; tetrahydrofuran / 1 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 4 h / Cooling with ice; Reflux

2.1: boron trifluoride diethyl etherate / dichloromethane / 18 h / -5 °C / Molecular sieve

3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C / Inert atmosphere; Cooling with ice

With 1H-imidazole; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1194045-07-2
2-bromo-1-fluoro-4-(prop-1-en-2-yl)benzene

: 1246248-65-6
{[3-(3-Bromo-4-fluorophenyl)but-3-en-1-yl]oxy}(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 18 h / -5 °C / Molecular sieve

2: 1H-imidazole / dichloromethane / 20 h / 20 °C / Inert atmosphere; Cooling with ice

With 1H-imidazole; boron trifluoride diethyl etherate; In dichloromethane;