(3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole

Base Information

Chemical Name:(3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole
CAS No.:1352447-36-9
Molecular Formula:C₁₉H₂₆O₆
Molecular Weight:350.412
Hs Code.:

Synonyms:(3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole

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Chemical Property of (3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole

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Technology Process of (3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole

There total 3 articles about (3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

: 1352447-35-8
((3aR,4R,6R,6aR)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d]-[1,3]dioxol-4-yl)methanol

: 106-95-6
allyl bromide

: 1352447-36-9
(3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole

Guidance literature:: ((3aR,4R,6R,6aR)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d]-[1,3]dioxol-4-yl)methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil;

allyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2011.10.063

Reference yield:

: 67814-68-0
2,3-O-isopropylidene-β-D-ribofuranose

: 1352447-36-9
(3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil

2.2: 12 h / 20 °C

With sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2011.10.063

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1352447-36-9
(3aR,4R,6R,6aR)-4-(allyloxymethyl)-6-(4-methoxybenzyloxy)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil

2.2: 12 h / 20 °C

With sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2011.10.063