(S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Base Information

Chemical Name:(S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
CAS No.:1196546-48-1
Molecular Formula:C₂₃H₁₇F₂N₅
Molecular Weight:401.418
Hs Code.:

Synonyms:(S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

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Chemical Property of (S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

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Technology Process of (S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

There total 8 articles about (S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196551-98-0
3-bromo-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

: 126747-14-6
4-cyanophenylboronic acid

: 1196546-38-9
(R)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

: 1196546-48-1
(S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 150 ℃; for 0.416667h; Microwave irradiation;

Reference yield:

: 399-94-0
2-bromo-1,4-difluorobenzene

: 1196546-38-9
(R)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

: 1196546-48-1
(S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogenchloride; water / methanol / 6 h / 70 °C

4.1: sodium tetrahydroborate / ethanol / 20 °C

5.1: potassium fluoride / dimethyl sulfoxide / 130 °C

6.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.42 h / 150 °C / Microwave irradiation

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; water; isopropylmagnesium chloride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide;

Reference yield:

: 886503-15-7,1217630-38-0
rac-2-(2,5-difluorophenyl)pyrrolidine

: 1196546-38-9
(R)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

: 1196546-48-1
(S)-4-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium fluoride / dimethyl sulfoxide / 130 °C

2: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.42 h / 150 °C / Microwave irradiation

With potassium fluoride; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dimethyl sulfoxide;