4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester

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Chemical Name:4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester
CAS No.:364780-61-0
Molecular Formula:C₄₀H₄₈O₁₂
Molecular Weight:720.814
Hs Code.:

Synonyms:4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester

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Chemical Property of 4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester

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Technology Process of 4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester

There total 5 articles about 4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 67-64-1
acetone

: 364780-60-9
4-(4-formyl-phenoxy)-butyric acid 2-benzyloxycarbonyl-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester

: 364780-61-0
4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester

Guidance literature:: acetone; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.5h;

4-(4-formyl-phenoxy)-butyric acid 2-benzyloxycarbonyl-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.583333h; Further stages.;
DOI:10.1021/ja001819f

Reference yield:

: 4767-03-7
2,2-bis(hydroxymethyl)propionic acid

: 364780-61-0
4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: KOH / dimethylformamide / 1 h / 100 °C

1.2: 60 percent / dimethylformamide / 15 h / 100 °C

2.1: 82 percent / TEA; DMAP / CH₂Cl₂ / 24 h / 20 °C

3.1: 85 percent / K₂CO₃; NaI / dimethylformamide / 24 h / 75 °C

4.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -78 °C

4.2: 65 percent / tetrahydrofuran; heptane; ethylbenzene / 0.58 h / -78 °C

With dmap; potassium hydroxide; TEA; potassium carbonate; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1021/ja001819f

Reference yield:

: 100-39-0
benzyl bromide

: 364780-61-0
4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyric acid 2-benzyloxycarbonyl-3-{4-[4-(1-hydroxy-3-oxo-butyl)-phenoxy]-butyryloxy}-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: KOH / dimethylformamide / 1 h / 100 °C

1.2: 60 percent / dimethylformamide / 15 h / 100 °C

2.1: 82 percent / TEA; DMAP / CH₂Cl₂ / 24 h / 20 °C

3.1: 85 percent / K₂CO₃; NaI / dimethylformamide / 24 h / 75 °C

4.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -78 °C

4.2: 65 percent / tetrahydrofuran; heptane; ethylbenzene / 0.58 h / -78 °C

With dmap; potassium hydroxide; TEA; potassium carbonate; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1021/ja001819f