6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Name:6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one
CAS No.:1460285-99-7
Molecular Formula:C₁₆H₁₄F₃N₃O₂
Molecular Weight:337.301
Hs Code.:

Synonyms:6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Property of 6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

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Technology Process of 6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

There total 5 articles about 6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1460285-98-6
4-(4-oxo-2-trifluoromethyl-4,5-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)benzoic acid methyl ester

: 676-58-4
methylmagnesium chloride

: 1460285-99-7
6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: 4-(4-oxo-2-trifluoromethyl-4,5-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)benzoic acid methyl ester; With cerium(III) chloride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

methylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 129768-30-5,948551-04-0
5-trifluoromethyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1460285-99-7
6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: ammonium acetate; acetic acid / 18 h / 110 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / toluene / 18 h / 100 °C / 1500.15 - 3150.32 Torr / Inert atmosphere; Autoclave

4.1: cerium(III) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cerium(III) chloride; ammonium acetate; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; acetone; toluene;

Reference yield:

: 1460286-55-8
2-[2-(4-bromo-phenyl)-2-oxo-ethyl]-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1460285-99-7
6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-trifluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate; acetic acid / 18 h / 110 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine / toluene / 18 h / 100 °C / 1500.15 - 3150.32 Torr / Inert atmosphere; Autoclave

3.1: cerium(III) chloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cerium(III) chloride; ammonium acetate; acetic acid; triethylamine; In tetrahydrofuran; toluene;