3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil

Base Information

• Chemical Name: 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil
• CAS No.: 127517-29-7
• Molecular Formula: C₂₉H₂₆N₂O₄
• Molecular Weight: 466.536
• Mol file: 127517-29-7.mol

Synonyms:3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil

Chemical Property of 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil

There total 5 articles about 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-methyl-2'-deoxy-3'-O-mesyl-5'-O-tritylpseudouridine (127517-28-6) → 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil (127517-29-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1021/jm00169a030

Reference yield:

Pseudothymidine (65358-15-8) → 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil (127517-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 89.6 percent / pyridine / 72 h / Ambient temperature

2: 66 percent / pyridine / 12 h / Ambient temperature

3: 94 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / dimethylformamide / 48 h / Ambient temperature

With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide;

DOI:10.1021/jm00169a030

Reference yield:

1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil (127517-34-4) → 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil (127517-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 5 mg / NaBH₄ / ethanol / 2 h / 0 °C

2: 66 percent / pyridine / 12 h / Ambient temperature

3: 94 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / dimethylformamide / 48 h / Ambient temperature

With pyridine; sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00169a030

upstream raw materials:

1-methyl-2'-deoxy-3'-O-mesyl-5'-O-tritylpseudouridine

Pseudothymidine

1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil

1-methyl-2'-deoxy-5'-O-tritylpseudouridine