1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil

Base Information

• Chemical Name: 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil
• CAS No.: 127517-34-4
• Molecular Formula: C₂₉H₂₆N₂O₅
• Molecular Weight: 482.536
• Mol file: 127517-34-4.mol

Synonyms:1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil

Chemical Property of 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil

There total 3 articles about 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-methyl-2'-deoxy-5'-O-tritylpseudouridine (78064-64-9) → 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil (127517-34-4)

Guidance literature:

With CrO₃*pyridine*acetic anhydride; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm00169a030

Reference yield:

Pseudothymidine (65358-15-8) → 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil (127517-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89.6 percent / pyridine / 72 h / Ambient temperature

2: 82 percent / CrO₃-pyridine-Ac₂O / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; CrO₃*pyridine*acetic anhydride; In dichloromethane;

DOI:10.1021/jm00169a030

Reference yield:

trityl chloride (76-83-5) → 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil (127517-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89.6 percent / pyridine / 72 h / Ambient temperature

2: 82 percent / CrO₃-pyridine-Ac₂O / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; CrO₃*pyridine*acetic anhydride; In dichloromethane;

DOI:10.1021/jm00169a030

upstream raw materials:

1-methyl-2'-deoxy-5'-O-tritylpseudouridine

Pseudothymidine

trityl chloride

Downstream raw materials:

1-methyl-2'-deoxy-3'-O-mesyl-5'-O-tritylpseudouridine

1-methyl-5-(2-deoxy-3-O-mesyl-5-O-trityl-β-D-threo-pentofuranosyl)uracil

3'-azido-2',3'-dideoxy-5'-O-trityl-1-methylpseudouridine

3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil