(E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid

Base Information

• Chemical Name: (E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid
• CAS No.: 146443-24-5
• Molecular Formula: C₂₁H₁₈O₄S
• Molecular Weight: 366.438
• Mol file: 146443-24-5.mol

Synonyms:(E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid

Chemical Property of (E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid

There total 3 articles about (E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-allyl-3,4-methylenedioxybenzene (94-59-7) → (E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid (146443-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / KOH / butan-1-ol / 3 h / Ambient temperature

2: 1.) POCl₃ / 1.) 0 deg C, 30 min., 2.) 110 deg C, 3 h

3: 1.) I₂, Zn, 2.) MeONa / 1.) benzene, reflux, 5 h, 2.) MeOH, reflux, overnight

With potassium hydroxide; iodine; sodium methylate; zinc; trichlorophosphate; In butan-1-ol;

DOI:10.1002/jps.2600811219

Reference yield:

isosafrole (4043-71-4) → (E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid (146443-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) 0 deg C, 30 min., 2.) 110 deg C, 3 h

2: 1.) I₂, Zn, 2.) MeONa / 1.) benzene, reflux, 5 h, 2.) MeOH, reflux, overnight

With iodine; sodium methylate; zinc; trichlorophosphate;

DOI:10.1002/jps.2600811219

Reference yield:

6-methyl-6,7-dihydro-2H,5H-indene[5,6-d][1,3]dioxol-5-one (51003-79-3) + ethyl bromoacetate (105-36-2) + 4-(Methylthio)benzaldehyde (3446-89-7) → (E)-2-methyl-(5,6-methylenedioxy)-1-(p-methylthiobenzylidene)-3-indenylacetic acid (146443-24-5)

Guidance literature:

With iodine; sodium methylate; zinc; Yield given. Multistep reaction; 1.) benzene, reflux, 5 h, 2.) MeOH, reflux, overnight;

DOI:10.1002/jps.2600811219

upstream raw materials:

6-methyl-6,7-dihydro-2H,5H-indene[5,6-d][1,3]dioxol-5-one

ethyl bromoacetate

4-(Methylthio)benzaldehyde

1-allyl-3,4-methylenedioxybenzene

Refernces