7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Base Information

Chemical Name:7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
CAS No.:77200-88-5
Molecular Formula:C₂₀H₂₅NO₃
Molecular Weight:327.423
Hs Code.:

Synonyms:7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

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Chemical Property of 7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

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Technology Process of 7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

There total 6 articles about 7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 78495-86-0
2-[2-(3,4-Dimethoxy-2-methyl-phenyl)-ethylamino]-1-(4-methoxy-phenyl)-ethanol

: 77200-88-5
7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: With sulfuric acid; trifluoroacetic acid; at 25 ℃; for 3.5h;
DOI:10.1021/jm00161a029

Reference yield:

: 637-69-4,24936-44-5
4-Methoxystyrene

: 77200-88-5
7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 5 steps

1: 86.4 percent / Br₂ / CH₂Cl₂ / -5 - 0 °C

2: 95 percent / MgSO₄, MgO / 1.25 h / Heating

3: 92 percent / K₂CO₃ / dimethylformamide / 2 h / 110 °C

4: 10percent aq. H₂SO₄ / Heating

5: 76 percent / TFA, 36 N aq. H₂SO₄ / 3.5 h / 25 °C

With sulfuric acid; bromine; magnesium oxide; magnesium sulfate; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00161a029

Reference yield:

: 19484-05-0
1-((4-methoxy)phenyl)-1,2-dibromoethane

: 77200-88-5
7,8-Dimethoxy-1-(4-methoxy-phenyl)-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / MgSO₄, MgO / 1.25 h / Heating

2: 92 percent / K₂CO₃ / dimethylformamide / 2 h / 110 °C

3: 10percent aq. H₂SO₄ / Heating

4: 76 percent / TFA, 36 N aq. H₂SO₄ / 3.5 h / 25 °C

With sulfuric acid; magnesium oxide; magnesium sulfate; potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00161a029